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It is currently not known whether the enhanced cough seen in disease states is due to peripheral or central sensitisation, and as such targeted therapeutics specific to the enhanced response are difficult to identify

Additionally, another study from 2016 reviewed the effects of nicotine on over 13,000 men and 6,000 women, confirming the trend that smoking is associated with higher testosterone levels in men, while no significant association was noted in women (Healthline)

Traditional e-cigarettes have two main characteristics that make them attractive to first-time vapers

Nationally, adult e-cigarette use prevalence was 7.7%.1 In 2022, 2.2% of adults in Illinois used smokeless tobacco every day or some days