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Snoek SA, Verstege MI, van der Zanden EP, Deeks N, Bulmer DC, Skynner M, Lee K, Te Velde AA, Boeckxstaens GE, de Jonge WJ: Selective alpha 7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis

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Nicotine is what causes the addiction, but other content in cigarettes is what causes the harm.It is the other 7,000 toxins and chemicals in tobacco which are most harmful, particularly tar and carbon monoxide

And these warning signs are what prevent overdose of nicotine