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This is because no clinical trials have specifically studied the tirzepatide-alcohol interaction it wasn't part of the SURPASS or SURMOUNT trial protocols

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N Engl J Med 2024;391:109-21.ArticlePubMed 77

Common triggers include allergens (such as pollen, dust mites, and pet dander), respiratory infections, physical activity, cold air, smoke, and strong emotions or stress

This is not because the medication becomes immediately harmful, but because reduced effectiveness can lead to poor blood sugar control over time, which is a more significant risk