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doi: 10.1007/s11356-022-18534-2

However, the oncological significance of GCG signaling remains insufficiently defined, and the currently available evidence does not support a uniform conclusion that GCGR activation exerts a direct antitumor effect (61)

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Insulin resistance and hyperinsulinaemia stimulate the production of androgens (male hormones present in both sexes) and reduce levels of sex hormone-binding globulin (SHBG)

Clinical implications : The FDAs acceptance of incremental weight loss as a primary endpoint provides a clearer regulatory pathway for this class of drugs