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As more groups worldwide use this technique, Denys said, a more systematic exploration, including randomised controlled trials of multiple centres and registries of cases are paramount to confirm the efficiency of LVD compared to other techniques such as PVE or Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS), the latter being associated with severe morbidity and mortality. In total, Denys et al identified 216 patients from centres in Switzerland, France, the USA, and the UK, the majority of whom had had a previous diagnosis of colorectal cancer or chloangiocarcinoma