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Endogenous danger signals secreted from cells under pathological stimuli, including cell-free DNA, modulate intracellular proinflammatory signaling in an autocrine/paracrine manner through TLRs on the cell surface [15]

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1995 Oncogene 10 : 14931499 Tretyakova N, Lin Y, Sangaiah R, Upton P, Swenberg J
For example, in Connecticut, reported age-adjusted incidence rates of lung cancer among males increased 220% between 193539 and 195054

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Zheng X, Liu B, Liu X, Li P, Zhang P, Ye F, et al