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They claimed that their products caused no adverse side-effects, with the apparent backing of "medical specialists." This advert claimed to prevent "throat irritation and coughing." It was considered uncouth for a woman to smoke at the turn of the 20th century, but as the Prohibition era came to an end, tobacco companies aggressively targeted the untapped female market

When we paid the tax, the revenue could be directed toward improving our health

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10.1016/j.matbio.2018.01.018 6 GuoH.SuY.DengF

Five Brothers Burley Five Brothers Pipe Tobacco (1.25 oz pouch) is a robust, no-frills Burley blend flavored by experienced pipe smokers seeking a straightforward, high-nicotine experience

R., & Paronis, C