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The central nicotinic cholinergic receptors, namely the low affinity 7 and the high affinity 42 nicotinic receptors located in the ventral tegmental area (VTA), are stimulated by nicotine resulting in a rapid release of dopamine in the nucleus accumbens, mediating the rewarding and reinforcing effects of nicotine (25) (Figure 1)

According to the CDCs Morbidity and Mortality Weekly Report from April 1, asymptomatic transmission increases the challenges of COVID-19 containment measures. Tactics like self-isolation or quarantines depend on early detection of potential infections, so without outward signs of illness, they become much less effective at slowing the disease