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For each slide, 4 points (at the 12, 3, 6, and 9 oclock positions) were measured and averaged

Furthermore, NAD + -consuming enzymes other than SARM1 have been reported to play a role in intracellular NAD + depletion during ageing-related neurodegenerative diseases

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NAD + is also a precursor to cyclic ADP-ribose (cADPR), a secondary signaling molecule generated by enzymes such as cluster of differentiation 38 (CD38) 7 , and it can be hydrolyzed by sirtuins, which deacetylate histones and regulate gene expression 7