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This was robustly demonstrated by Vassallo et al (33), who sensitized DR4 and DQ8 mice to CII with two distinct protocols varied by when CS exposure occurred, either before or after CII sensitization

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(2020) Comparative Effects of Varenicline or Combination Nicotine Replacement Therapy versus Patch Monotherapy on Candidate Mediators of Early Abstinence in a Smoking Cessation Attempt