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After 1815, the market for wheat contracted, and in the 1830s southeastern Pennsylvania farmers began raising seed leaf tobacco (used as cigar filler) commercially

28 May 2002

combined with the lack of transportation, manufacturers did not have the infrastructure to support a national demand for their items

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Over a career in the Public Health Service that spanned five decades, he served as an editor of 17 reports of the Surgeon General on smoking and health, interim director of the Office on Smoking and Health, and advisor on smoking and health at the National Cancer Institute

Journal of Substance Abuse