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The economic impact of the disease is also of great concern as the total costs of the disease in the US are estimated to be $4.9 billion annually (2)

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There are few if any attempts, however, to systematically and comprehensively evaluate the landscape of evidence on smoking risk across a diverse range of health outcomes, with most current research focusing on risk or attributable burden of smoking for a specific condition 7,15 , thereby missing the opportunity to provide a comprehensive picture of the health risk experienced by smokers