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Whereas most of the included studies were varied in quality from low to high, most studies had small sample size and only two had large sample size, participants were predominantly male, used different comparison groups, done at different settings, most of the studies were done in the USA, and some of the studies did not report the related findings of NRT effect

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However, for first-time vapers or those with little experience, this level of nicotine can be overwhelming

The chart below shows a typical nicotine withdrawal timeline curve

The Costco case configuration (item #697447, referenced internally as #10150) is a 6-master-case quantity, making it suitable for wholesale or club-format purchasing