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(2020) Nitric oxide and S-nitrosylation in cancers: emphasis on breast cancer, Breast Cancer (Auckl) , 14 , 1178223419882688, Gorrini, C., Harris, I
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Males have approximately 19 times more testosterone in their blood compared to females and it was shown by Schwahn et al

Further involved in estrogen activity , ESR1 and ESR2 encode estrogen receptor alpha (ERalpha) and beta (ERbeta)

Targeting Downstream Effectors of ER Activation While ER-targeted therapies are likely to suffer from some of the same risks as estrogen supplementation (115), targeting selected downstream effectors of ER may represent an opportunity to capture the metabolic benefits while bypassing adverse effects associated with estrogens

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