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Tobacco-derived nicotine is separated using solvent extraction and purified through distillation or chromatography

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Inflammatory cascade : Vapors upregulate pro-inflammatory cytokines (TNF-, IL-6, IL-1) within hepatic tissue, driving steatohepatitis and early fibrosis [120, 130]

Cambridge: Cambridge University Press, 2004

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If you note that we are not a democracy, but a republic, you risk being mocked as strict constructionists overly wedded to technical definitions and unwilling to acknowledge the importance of popular sovereignty and the will of the people in our system