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In a recent systematic review that comprised data from five studies, it was suggested that smokers have adverse disease outcomes, are 1.4 times more likely to manifest typical symptoms of COVID-19 i.e dry cough, fever, sore throat, muscle/joint pains, diarrhea and require more intensive care and ventilation than nonsmokers.[] Scientific Data has found worsening of COVID-19 infection in hospitalized patients addictive to smoking, nicotine has been found to increase the expression of ACE-2, which in turn modulates the nicotine acetylcholine receptor.[] Miyara et al

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