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In clinical studies, the level of surfactant has been evaluated as an important factor in determining the outcome and mortality rate among patients, who developed ALI and ARDS induced by SARS-CoV-2

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doi: 10.1016/j.diabres.2020.108487

This work first noted the decreasing expression of GLP-1R in degenerative cartilage, indicating the dysfunction of GLP-1R pathway during the process of OA

The STEP trials for semaglutide and the SURMOUNT trials for tirzepatide each enrolled tens of thousands of participants over periods of one to two years