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The magnitude of the increase in plasma levels is also affected by the degree to which a drug that is metabolized by intestinal CYP3A4 is also metabolized by other hepatic enzymes, including other isoforms of P450
( 10.1210/clinem/dgae149) [DOI] [PMC free article] [PubMed] [Google Scholar] 36.Montague CT, Farooqi IS, Whitehead JP, et al
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Lately, GSK-3 has been identified as an alternative target for drug-mediated neuroprotective effects against excitotoxicity of ischemic stroke in animal models because GSK-3 is a multifaceted protein with a variety of neurophysiological and cellular effects
