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A follow up study using radio-ligand PET technology to measure receptor occupancy demonstrated a high degree of GLP-1R occupancy but no detectable GCGR occupancy suggesting that in vivo SAR425899 may be acting in effect as a GLP-1 analogue and not a co-agonist (87)

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If neck pain persists or worsens, discuss it with your doctor to determine if the medication is related

Tell your healthcare provider if you have any new or worse symptoms of heart failure including: shortness of breath, swelling of your ankles or feet, sudden weight gain Treatment with TZDs and TOUJEO may need to be changed or stopped by your healthcare provider if you have new or worse heart failure