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Within 5-10 years, the GLP-1 therapy landscape will likely include multiple oral options at various price points, fundamentally changing how metabolic disease is managed in primary care

Consequently, in the forthcoming period, it is imperative to conduct in-depth investigations into the specific molecular mechanisms underlying the anti-inflammatory and immunomodulatory properties of GLP-1RAs in psoriasis

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In contrast, recommendations for treatment selection in the second-line setting have been outlined in international guidelines, such as the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) guidelines, which inform choice of treatment according to an individuals CV and chronic kidney disease (CKD) risk [15]

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