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In November 2021, the EMA extended the dose of once-weekly subcutaneous semaglutide up to 2 mg for the treatment of T2D

da Silva Fernandes J, Schuelter-Trevisol F, Cancelier ACL, et al

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In contrast to GIP, GLP-1 was found to retain its insulinotropic effect in patients, and this fact provides part of the background for the clinical use of GLP-1 receptor agonists in diabetes treatment

2.2 Historical reasons for underexploration Across peptide systems, several recurring factors have contributed to underexploration

However, several challenges need to be addressed to optimize their clinical utility