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Therefore, we sought a less-sensitive functional assay with reduced receptor expression levels to enable the optimization of efficacy-driven GLP-1R agonists for clinical development

Moreover, we found that the expression of GLP-1 signaling-related genes ITPR1 and ADCY5 were significantly reduced in CRC tissues, and GLP-1 receptor agonist semaglutide impaired the migration capacity of CRC cells, indicating its protective role

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Is it safe to microdose GLP-1 with methotrexate or biologics

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