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They lose their muscle

Glucagon suppresses food intake by acting in the brain [76] and increases energy expenditure by stimulating thermogenesis in peripheral tissues [74]
STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

6,9 Individuals with T2D should be categorised into different CV risk groups ( Table 1 )

JAMA Cardiology

Abdul-Ghani MA, DeFronzo RA, Norton L (2013) Novel hypothesis to explain why SGLT2 inhibitors inhibit only 3050% of filtered glucose load in humans
