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These findings underscore the potential for GLP-1 RAs to offer tailored protection against complex diabetic complications, marking an advancement in personalized medicine for managing diabetes-acute kidney disease.

These results provide new insights into the molecular basis of ligand specificity in class B GPCRs and may facilitate the development of more specific therapeutics.

A population-based cohort study of nearly 114,000 patients with T2D found that use of GLP-1s, compared with SGLT-2 inhibitors, was associated with a 27% higher relative risk of being diagnosed with GERD and a 55% higher relative risk of GERD-related complications

By pairing a rapid "research flywheel" with large-scale genomic data, 23andMe Research Institute scientists identified GLP1R and GIPR variants associated with some of the variability in individual response to GLP-1 drugs, helping bridge the gap between patient experiences and precision medicine.

Benefits: Supports gradual fat loss by creating a healthier, more sustainable weight management environment