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In addition, whether early initiation of GLP-1RA in patients with newly diagnosed T1D can preserve cell function remains to be determined in large RCTs

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GIPR, unlike the GLP1R, is extensively expressed in the ventricular myocardium of both rodents and humans

So cardiologists will need to counsel patients through that and acclimate them to giving these drugs by subcutaneous injection. His colleague Dennis Bruemmer, MD, PhD, Director of Cleveland Clinics Center for Cardiometabolic Health, already has considerable experience using these drugs for diabetes and weight loss