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Although chronic intracerebroventricular infusion of native LEAP2 decreases body weight and ghrelin-induced weight gain [30, 90], these findings should primarily be considered proof-of-concept pharmacological effects, as the physiological relevance of endogenous central LEAP2 signalling remains uncertain

Whether the initial launch price will be meaningfully lower than injectable GLP-1 agonists remains to be seen

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This phenomenon is concurred by Zhao Y., et al

It is imperative to include the therapies targeting most of the pathophysiological derangements in diabetes

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