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Samaniego], [Nicole Norma Gamarra-Valverde], [Andrea Tripoli], [Juan Pinilla], [Macarena Lopez], [Vinh Quang Tri Ho], and [Salomon Chamay]

Dietary fibre , especially soluble and fermentable types, undergoes bacterial fermentation in the colon, producing short-chain fatty acids (SCFAs) such as butyrate, propionate, and acetate

Statements Author contributions BX, SC, and YX have equally contributed to this manuscript

MS lesions can appear throughout the CNS and are most easily recognized in the white matter as focal areas of demyelination, inflammation, and glial reaction [113]

Some patients benefit from medication months to years after surgery, once weight regain begins, appetite noticeably increases, or lifestyle efforts alone are no longer enough

By year four, fewer than half of those who achieved clinically significant loss had maintained it