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If the GI AEs are intolerable to the patient after several weeks following uptitration, the patient could be moved back to a lower dose
47 Substitution of Lys 26 for Asn bearing N -acetylglucosamine (GlcNAc), N -acetyllactosamine (LacNAc), or -2,6-sialyl- N -acetyl-lactosamine (sialyl LacNAc) resulted in a moderate loss of binding affinity and potency (2- to 8-fold) but higher resistance to the DPP-IV degradation compared to GLP-1
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Likely impacts of recruitment site and methodology on characteristics of enrolled patient population: irritable bowel syndrome clinical trial design
They just solve the problem in almost opposite ways
Doi: 10.1111/dom.16042 [DOI] [PMC free article] [PubMed] [Google Scholar] 152
