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The curcumin RCT showing significant HbA1c improvements ran 12 months

For some, staying on a lower maintenance dose for long-term success is a viable option

The FDA approved the use of semaglutide to decrease the risk of kidney failure and disease progression, as well as death from cardiovascular disease in adults with type 2 diabetes and chronic kidney disease in January 2025 based on outcomes of the FLOW trial [130]

According to several studies, individuals taking semaglutide have seen greater reductions in body weight compared to those using other weight loss medications or lifestyle changes alone

Blood glucose fluctuations may also play a role

Solinas and Becattini 2017