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Methods: We searched PubMed, Scopus, Cochrane Library, Google Scholar, and Web of Science (ClinicalTrials.gov for unpublished records) from their inception to 5 February 2025, including observational cohort studies and randomized controlled trials

When blood levels are adequate and weight has plateaued, the explanation is almost never tolerance but rather achievement of equilibrium weight

Determining when a skin reaction requires medical attention is crucial for patient safety

With slowed gastric emptying, the lower oesophageal sphincter sees more sustained pressure from the contents below, and reflux symptoms become more likely

The SUSTAIN trial series showed that patients receiving ongoing semaglutide maintained 80% or more of their initial weight loss over three years, compared to rapid regain in placebo groups

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