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External resources FDA Prescribing Information for Mounjaro (Tirzepatide) - Official prescribing information including complete side effect data from clinical trials New England Journal of Medicine SURPASS Trials - Primary clinical trial data on tirzepatide efficacy and safety National Academies Dietary Reference Intakes for Water - Evidence-based hydration guidelines for adults Daniels et al
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Sustained Progress: Months 46 and Beyond By month 4, most semaglutide patients have achieved 10-15% weight loss from baseline, with some reaching 20% or higher depending on individual metabolism, genetics, and lifestyle factors

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Oprah weighed 237lbs (107.5kg) at her heaviest, she has previously revealed

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