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Mechanistic studies found that BA1b promoted the secretion of incretin (GIP and GLP-1) by up-regulation of VDAC1 gene expression levels

Conclusion GLP-1 RA use was associated with substantially reduced all-cause death but a small increased risk of acute pancreatitis, particularly during early treatment

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Others, including taspoglutide, failed through high incidence of side-effects or insufficient efficacy

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