semaglutide patent expiry 2031 The story: highlighting the need to maintain protection in Canada When do the patents on

N Engl J Med 359(15):15771589 Holman RR, Bethel MA, Mentz RJ, Thompson VP, Lokhnygina Y, Buse JB, EXSCEL Study Group et al (2017) Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes

GLP-2 GLP-2 is a 33-amino acid peptide secreted from intestinal L-cells in a 1:1 ratio with GLP-1

First, if the solution has become contaminated with bacteria due to improper storage of a multi-dose vial, injection carries a risk of infection

Strengths and limitations The GLIDE clinical trial has several strengths

According to FDA labeling, the development of anti-semaglutide antibodies is infrequent and has not been observed to meaningfully impact the efficacy or pharmacokinetics of the medication in clinical trials

Armstrong MJ, Gaunt P, Aithal GP et al (2016) Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study