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Obesity contributes to renal damage through hemodynamic changes, including glomerular hyperfiltration and increased renal plasma flow, which over time lead to glomerular hypertrophy and focal segmental glomerulosclerosis (4)

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and so the doses did not exceed 1.8mg, which is the indicated dose for such patients

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The most frequent adverse reaction that led to this discontinuation was because of nausea and vomiting