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Oral semaglutide delivered meaningful reductions in HbA1c and body weight among GLP-1RA-nave adults with type 2 diabetes in a Dutch real-world cohort

Effectiveness and Impact Significant Weight Loss: Phase 2 studies showed up to roughly 20% average body weight loss at 52 weeks in participants with obesity

Reduced risk of side effects

Evidence-based weight loss with medical guidance, coaching, and habit support

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however, it could be related to a direct effect at the sinus node and/or stimulation of the sympathetic nervous system, with this effect related to the duration of action of the respective GLP-1 RAs