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Timing considerations when switching medications If you are switching from semaglutide to tirzepatide or going the other direction , timing the transition correctly matters

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In our bodies, incretin can be regulated by dietary fibre and fermented foods

However, clinical trials have been known to show that tirzepatide can be a significant factor in lessening the risk of type 2 diabetes by up to 10 years in people with overweight or obesity

At present, it would be prudent to consider an HbA1c target of 58 mmol/mol for most patients with type 2 diabetes and DN-CKD if they are on an insulin-dominant regime, and a target of up to 68 mmol/mol in older patients with more advanced CKD, especially where they have renal anaemia

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