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GLP-1 medications like Ozempic, Wegovy, and Zepbound reduce appetite and slow digestion, which often produces rapid, substantial fat loss

N Engl J Med 2021;384:1113-24.ArticlePubMed 120

Setmelanotide Setmelanotide is a melanocortin-4 receptor (MC4R) agonist approved to treat genetic obesity due to pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiencies, as well as BardetBiedl syndrome (BBS), in patients aged 2 years and older [45,46,47]

[Google Scholar] 440.Bartesaghi S, et al