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Despite their widespread use and good safety profile, recent studies have documented a possible association between GLP-1 RAs and NAION

109 Meta-analyses of caloric restriction trials have also confirmed that the degree of BMD loss is proportional to the magnitude of body mass reduction, especially at load-bearing sites like the femoral neck and total hip

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For weight management medications, NICE guidance specifies different stopping rulesfor example, Wegovy treatment should be reviewed after 6 months, and Saxenda should be discontinued if less than 5% weight loss is achieved after 12 weeks at the maintenance dose