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All decisions described here are made in line with the Patient Group Directions (PGDs) under which DoseDirect operates

The phase 3a trial showed that while adverse events were more frequent with SMG compared to sitagliptin, its overall safety profile was similar to that of other GLP-1 receptor agonists [60]

Diet: It is important to emphasize that GLP-1s work only if the patient is on a calorie deficit - about 1600 calories per day

CCK functions in an autocrine manner by binding to the cholecystokinin type A receptor (CCK-AR), inhibiting channel activation and increasing intracellular Ca2+ by up to 30% upon TAS2R stimulation (73)

Supporting information Acknowledgements The authors appreciate Animal Resources Facility and Winship Cancer Tissue and Pathology at Emory University School of Medicine (Winship Cancer InstituteNIH 5P30CA138292)