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35 A total of 56 patients was assessed using the ChildPugh criteria and grouped into either normal, mild, moderate, or severe hepatic impairment

ArticlePubMed 27

However, the limited follow-up duration of 6 months raised concerns about potential reverse causality, as undetected suicidal ideation and medical conditions might have influenced the choice of particular anti-obesity or anti-diabetic drugs

The study has several important caveats

The rate of weight loss may also influence the degree of cold intolerance, though this observation is primarily based on clinical experience rather than controlled studies
