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While some preclinical research has explored potential immunomodulatory effects of GLP-1 receptor agonists, there is currently insufficient clinical evidence to establish this as a mechanism for systemic symptoms in patients taking tirzepatide

Patients need to know what they're signing up for

GLP-1 is a weekly injection given in our office using a very fine needle, making them virtually painless

If a patients weight is stable or decreasing then continued reduction of dosage and eventual discontinuation of the drug can safely happen, she explains

And a path to bariatric surgery if appropriate, he said, adding that the program delivers 19% sustained weight loss at 36 months