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This process will take time and will require resources for primary care training and the development of sustainable pathways

Weight loss from Mounjaro may indirectly influence hormonal systems, but this represents an effect of weight reduction rather than direct pharmacological action on adrenal glands

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Seek immediate medical attention for the following warning signs: Severe abdominal pain , particularly if persistent or radiating to the back, which may indicate pancreatitis (a rare but serious adverse effect) Persistent vomiting that prevents adequate fluid intake Signs of dehydration including decreased urination, dark urine, dizziness, dry mouth, or confusion Hypoglycemia symptoms such as shakiness, sweating, rapid heartbeat, hunger, confusion, or irritability (especially in patients taking insulin or sulfonylureas) Symptoms of gallbladder disease such as right upper abdominal pain, fever, or jaundice (yellowing of skin or eyes) Severe constipation or inability to pass stool or gas, accompanied by abdominal distention Signs of allergic reaction including rash, swelling of face/tongue/throat, or difficulty breathing (call 911) Patients with type 2 diabetes should monitor blood glucose levels more frequently during periods of significant nausea or vomiting, as reduced food intake can affect glycemic control

In a Semaglutide Treatment Effect in People with Obesity (STEP) trial, semaglutide 2.4 mg plus lifestyle modification produced substantial, durable weight loss beyond lifestyle alone 13

The obesity market is changing at pace, and 2025 will be a critical year for its development