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Semaglutide activates GLP-1 receptors in your brain to reduce hunger and slow stomach emptying, but weight loss doesn't happen overnight

However, this same effect creates the physiological basis for common adverse effects including nausea, vomiting, early satiety, bloating, and belching

Severe dehydration from prolonged vomiting can cause kidney injury, especially in older adults or those with existing renal disease

Meanwhile, it has a longer half-life (9.57 h) than GLP1 (about 2 min) because it lacks a specific site for DPP-IV hydrolase and is resistant to the rapid enzymatic digestion of DPP-IV (Zhang and Chen, 2012)

Mechanisms Compared: How Each Drug Works Think of treatment as a conversation between gut and brain: semaglutide copies GLP1, boosting insulin, slowing gastric emptying, and heightening fullness to cut appetite

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