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Your brain interprets pain signals through the filter of your expectations and emotional state
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The Big 2025 (and Beyond) Question One theme that emerged from JPM 2025 was the uncertainty that arose from the new administration

PMID: 40806889
10.1152/ajpgi.90578.2008 377

A) Activation of POMC neurons by GLP-1 and 5-HT, particularly through the 5-HT2C receptor, leads to the release of -MSH, an endogenous agonist for MC4R
