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When administered directly into the arcuate nucleus of rats, GLP-1 decreases hepatic glucose production under clamped conditions where glucose and insulin were held constant (209)
Lilly showed in recently announced clinical trial results that patients who switched to orforglipron after losing weight on either Wegovy or Zepbound regained less weight than participants who switched to a placebo
In head-to-head clinical trials, tirzepatide showed greater average weight reduction than semaglutide
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