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have largely been successful at achieving these goals

tirzepatide is a dual agonist (GLP-1 plus gastric inhibitory polypeptide, GIP)

First, weight loss is a reproducible finding over a 36-months window, and in many cohorts the mean reduction reaches ranges commonly considered clinically meaningful for reproductive planning (often cited around 5% of baseline weight), with some studies reporting larger decreases

Patients should be educated to be aware that they may experience GI AEs, and that these will probably be mild to moderate in intensity and transient

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