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Absolute contraindications to GLP-1 receptor agonists include: Personal history of medullary thyroid carcinoma Family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Pregnancy (for weight management indications) Severe gastrointestinal disease, including gastroparesis Patients should be specifically questioned about these conditions during pre-treatment evaluation

If you drink excessively, then it may instead increase the risk of hypoglycemia

Sustainable weight loss is most likely to be achieved by combining GLP-1 therapy with healthy habits like a nutritious, balanced diet, regular exercise, and adequate sleep

1 So the honest version of the question is not how does it work in PCOS? but is there a defensible reason to think it would improve insulin resistance in PCOS, and how far can we reason from the data that actually exist? That reframing is not evasion

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The amylin pathway is distinct from both GLP-1 and GIP signaling