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It is especially relevant for patients taking or researching semaglutide, tirzepatide, GLP-1 injections, oral GLP-1 options, or physician-supervised weight loss programs
The biggest culprits are clozapine and olanzapine
Understanding these differences matters if you are transitioning between compounds or considering alternatives
This avoids the weight regain risk of a full drug holiday
Inhibition of glucagon secretion or antagonism of glucagon receptors has become a potentially effective treatment strategy for T2DM patients (Lund et al., 2014)
In parallel, a phase 4 RCT (NCT07111494) will compare GLP-1RAs with nutritional counseling in PsA patients with obesity and T2DM, incorporating both clinical and patient-reported outcomes
