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Effects on Glycemic Control : DPP-4 inhibitors prevent the inactivation of incretin hormones (glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP))

The GLP-1 mechanism of action also explains why results accelerate over time rather than plateauing immediately like most diets

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Clinical Medicine, 25(2), 100298

doi: 10.1016/j.cels.2016.09.002

Hence, this leads these hormones to work for a longer time, and as a consequence, pancreatic -cells become more sensitive to increases in blood glucose, causing the release of insulin and a decrease in glucagon