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However, DPP-4 affects many other pathophysiological pathways, not only limited to the regulation of glucose homeostasis and T2D, with multiple effects on inflammation, oxidative stress, and immune response, retaining a key role in the pathogenesis of cardiovascular disease (Table 2)

95% CI 0.381.93

All major GLP-1 medications typically fall under pharmacy benefit prior authorization programs, often as tier-2 specialty or tier-3 drugs

STEP 4 randomised people whod lost 10.6% on semaglutide to either continue the medication or switch to placebo

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Rohwer N, Hage R, El, Smyl C, Ocvirk S, Goris T, Grune T et al